RWE

Risk of stroke, myocardial infarction, coronary intervention, and atrial fibrillation or flutter in individuals experiencing typical migraine aura without headache - a Danish registry-based cohort study

Migraine aura without headache was previously described as a benign condition. We investigated an association between migraine aura without headache and risks of stroke, myocardial infarction (MI) or percutaneous coronary intervention (PCI), coronary …

Associations between mRNA COVID-19 vaccination and urticaria - a nationwide registry-based cohort study in Denmark

Following the most recent mRNA vaccination dose, Moderna vaccine schedule adherers had a higher than expected incidence of chronic and other types of urticaria. We found no association between other vaccination schedule and increased risk of …

Risk of diabetes and cardiovascular diseases in women with vaginal bleeding before 20 gestational weeks - Danish population-based cohort study

Women’s reproductive health is associated with cardiovascular morbidity. However, an association of vaginal bleeding (VB) in pregnancy with diabetes and cardiovascular outcomes has scarcely been investigated. We conducted a population-based cohort …

Introduction to the main Danish health and administrative registries

Accounting for bias in single arm trials with external comparator arm

Confounding and selection bias in pharmacoepidemiology

Association between vaginal bleeding in pregnancy that resulted in delivery and risk of cancer– a Danish registry-based cohort study

Vaginal bleeding (VB) before 20 gestational weeks of a viable pregnancy is a manifestation of a threatened miscarriage. VB is associated with increased levels of pro-inflammatory cytokines such as interferon-gamma, tumour necrosis factor-alpha and …

Association between pregnancy affected by vaginal bleeding and women's mortality – a Danish cohort study

We aimed to investigate the association between vaginal bleeding (VB) in pregnancy and women's mortality, using VB-unaffected pregnancies, terminations and miscarriages as comparators. This was an observational cohort study using nationwide …

Prenatal exposure to pregabalin, birth outcomes and neurodevelopment – a population‑based cohort study in four Nordic countries

Prenatal pregabalin exposure compared with no exposure showed a 1.1-fold association (95% CI 0.98–1.32) with the prevalence of any major congenital malformation among live and stillborn offspring, and a 1.7-fold association (95% CI 1.02–2.91) with stillbirth; the association was attenuated in Mantel–Haenszel meta-analysis for the latter outcome. We found no association between prenatal pregabalin exposure and risks of birth outcomes other than major congenital malformations or stillbirth. Prenatal exposure to pregabalin compared with no exposure to pregabalin and active comparators showed a 1.3-fold association (95% CI 1.03–1.63) with attention deficit/hyperactivity disorder; the association was attenuated in the analyses using active comparators and Mantel–Haenszel meta-analysis. There was no evidence of an association with other examined neurodevelopmental postnatal outcomes.

Discussing Emulating target trials for interventions during pregnancy